Özet:
Bu çalışmanın 1. bölümünde 5 adet doğal madde; 5,7,4'-trihidroksi-3'-metoksiflavon- 8-C-P-D-zaylopranozid-2"-0-glikozid (1 ), 5,7-dihidroksi-3'-metoksi-4'-asetoksiflavon-8-C- p-D-zaylopranozid-2"-0-glikozid (2), 5,7,4'-trihidroksi-3'-metoksiflavon-8-C-p-D- zaylofuranozid-2'*-0-glikozid (3, 2-metil-3-0- {2'-[p-D-glikozid-( 1 m-*3")-P-D-glikozid]- propioniloksi-4'-metoksifenil}-4-piron (4), maltol-P-D-glikopranozid (5), Scleranthus uncinatus bitkisinin metanol ekstraktından çeşitli kromatografik yöntemler kullanılarak ilk defa izole edilip, yapılan modern NMR teknikleri ve (+) FAB kütle spektrumları kullanarak aydınlatıldı. Literatür araştırması sonucu 1-4 nolu maddelerin yeni ve 5 nolu madde ise bilinen olduğu tespit edildi. Çalışmanın 2. bölümünde ise heterohalkalı kalkanoid türü 1 2 adet madde sentezlendi. Bu bileşiklerden 6 ve 7 nolu maddelerin yeni olduğu tespit edildi. Sentez edilen maddelerin antioksidan özellikleri incelenmiş olup, 7, 9 ve 15 nolu maddelerin oldukça yüksek antioksidan aktiviteye sahip oldukları bulundu.
SUMMARY Structure Elucidation of Natural Compounds from the Metahnolic Extract of Scleranthus uncinatus (Illecebraceae) Plant and Synthesis of Heterocyclic Chalcanoid Type of Compounds, Investigation of Their Antioxidant Activities In the first part of this work, five natural compounds; 5,7,4'-trihydroxy-3'- methoxyfiavone-8-C-P-D- xylopyranoside-2"-0-glucoside (1), 5,7-dihydroxy-3'-methoxy- 4'-acetoxyflavone-8-C-P-D-xylopyranoside-2"-0-glucoside (2), 5,7,4'-trihydroxy-3'- methoxyflavone-8-C-p-xylofuranoside-2"-0-glucoside (3), 2-methyl-3-0- {2'-[p-D- glucoside-(l"'- >3")-p-D-glucoside]-propionyIoxy-4'-methoxyphenyl } -4-pyrone (4) and maltol p-D-glucopyranoside (5) were isolated for the first time using various chromatographic techniques from the metahnolic extract of Scleranthus uncinatus and their structures were identified by modern nmr techniques and (+) FAB mass spectra. As a result of the literature review, it was determined that compound 1-4 were new compounds and compound 5 found to be known a natural compound. In the second part of this work, 12 heterocyclic chalcanoid type of compounds were synthesized. Of these compounds, 6 and 7 were found to be new. Antioxidant activities for the synthetic compounds were investigated. It was found that compound 7, 9 and 15 showed highly antioxidant activity.
